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Titel:

Deletion of exon 8 increases cisplatin-induced E-cadherin cleavage.

Dokumenttyp:
Journal Article
Autor(en):
Fuchs, M; Hermannstädter, C; Hutzler, P; Häcker, G; Haller, F; Höfler, H; Luber, B
Abstract:
E-Cadherin-mediated cell-cell adhesion plays a key role in epithelial cell survival and loss of E-cadherin or beta-catenin expression is associated with invasive tumor growth. Somatic E-cadherin mutations have been identified in sporadic diffuse-type gastric carcinoma. Here, we analysed the fate of E-cadherin with an in frame deletion of exon 8 compared to wild-type E-cadherin and the involved signalling events during cisplatin-induced apoptosis. We report that mutant E-cadherin was more readily...     »
Zeitschriftentitel:
Exp Cell Res
Jahr:
2008
Band / Volume:
314
Heft / Issue:
1
Seitenangaben Beitrag:
153-63
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.yexcr.2007.09.004
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17959171
Print-ISSN:
0014-4827
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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