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Title:

Enhanced activation of epidermal growth factor receptor caused by tumor-derived E-cadherin mutations.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Bremm, A; Walch, A; Fuchs, M; Mages, J; Duyster, J; Keller, G; Hermannstädter, C; Becker, KF; Rauser, S; Langer, R; von Weyhern, CH; Höfler, H; Luber, B
Abstract:
Mutations of the tumor suppressor E-cadherin and overexpression of the receptor tyrosine kinase epidermal growth factor receptor (EGFR) are among the most frequent genetic alterations associated with diffuse-type gastric carcinoma. Accumulating evidence suggests a functional relationship between E-cadherin and EGFR that regulates both proteins. We report that somatic mutation of E-cadherin is associated with increased activation of EGFR followed by enhanced recruitment of the downstream acting s...     »
Journal title abbreviation:
Cancer Res
Year:
2008
Journal volume:
68
Journal issue:
3
Pages contribution:
707-14
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-07-1588
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18245470
Print-ISSN:
0008-5472
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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