Login
- Title:
Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients.
- Document type:
- Journal Article; Research Support, Non-U.S. Gov't
- Author(s):
- Aubele, M; Walch, AK; Ludyga, N; Braselmann, H; Atkinson, MJ; Luber, B; Auer, G; Tapio, S; Cooke, T; Bartlett, JM
- Abstract:
- The cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis. Using immunohistochemistry, we performed a retrospective study on 426 archival breast cancer samples from patients with long-term follow-up and compared the protein expression levels of PTK6, the HER receptors, Sam68 (a substrate of PTK6), and signalling proteins including MAP kinase (MAPK), phosphorylated MAPK (P-MAPK), and PTEN. We show that PTK6 expression is of significant prognostic value in the outcome of breast carcinomas. In multivariate analysis, the disease-free survival of patients of >or=240 months was directly associated with the protein expression level of PTK6 (P
- Journal title abbreviation:
- Br J Cancer
- Year:
- 2008
- Journal volume:
- 99
- Journal issue:
- 7
- Pages contribution:
- 1089-95
- Language:
- eng
- Fulltext / DOI:
- doi:10.1038/sj.bjc.6604660
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/18781181
- Print-ISSN:
- 0007-0920
- TUM Institution:
- Institut für Allgemeine Pathologie und Pathologische Anatomie
BibTeX