Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients.

Titel:: Prognostic value of protein tyrosine kinase 6 (PTK6) for long-term survival of breast cancer patients.
Dokumenttyp:: Journal Article; Research Support, Non-U.S. Gov't
Autor(en):: Aubele, M; Walch, AK; Ludyga, N; Braselmann, H; Atkinson, MJ; Luber, B; Auer, G; Tapio, S; Cooke, T; Bartlett, JM
Abstract:: The cytoplasmic tyrosine kinase PTK6 (BRK) shows elevated expression in approximately two-thirds of primary breast tumours, and is implicated in EGF receptor-dependent signalling and epithelial tumorigenesis. Using immunohistochemistry, we performed a retrospective study on 426 archival breast cancer samples from patients with long-term follow-up and compared the protein expression levels of PTK6, the HER receptors, Sam68 (a substrate of PTK6), and signalling proteins including MAP kinase (MAPK), phosphorylated MAPK (P-MAPK), and PTEN. We show that PTK6 expression is of significant prognostic value in the outcome of breast carcinomas. In multivariate analysis, the disease-free survival of patients of >or=240 months was directly associated with the protein expression level of PTK6 (P
Zeitschriftentitel:: Br J Cancer
Jahr:: 2008
Band / Volume:: 99
Heft / Issue:: 7
Seitenangaben Beitrag:: 1089-95
Sprache:: eng
Volltext / DOI:: doi:10.1038/sj.bjc.6604660
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/18781181
Print-ISSN:: 0007-0920
TUM Einrichtung:: Institut für Allgemeine Pathologie und Pathologische Anatomie
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