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Titel:

EGFR-dependent migration of glial cells is mediated by reorganisation of N-cadherin.

Dokumenttyp:
Journal Article
Autor(en):
Rappl, A; Piontek, G; Schlegel, J
Abstract:
Receptor tyrosine kinases of the EGFR family exert their various effects on cellular function through the formation of different dimeric receptor complexes. To investigate the functional impact of EGFR-HER2 heterodimers on migration of glial tumour cells, we stably transfected different HER2 constructs, including a constitutively active (HER2VE) and a dominant-negative (HER2VEKA) receptor, in the EGFR-overexpressing human glioma cell line LN18. Interference of EGFR activation through HER2VEKA in...     »
Zeitschriftentitel:
J Cell Sci
Jahr:
2008
Band / Volume:
121
Heft / Issue:
Pt 24
Seitenangaben Beitrag:
4089-97
Sprache:
eng
Volltext / DOI:
doi:10.1242/jcs.027995
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19033391
Print-ISSN:
0021-9533
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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