User: Guest  Login
Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Chan, CY; Kiechle, M; Manivasakam, P; Schiestl, RH
Title:
Ionizing radiation and restriction enzymes induce microhomology-mediated illegitimate recombination in Saccharomyces cerevisiae.
Abstract:
DNA double-strand breaks can be repaired by illegitimate recombination without extended sequence homology. A distinct mechanism namely microhomology-mediated recombination occurs between a few basepairs of homology that is associated with deletions. Ionizing radiation and restriction enzymes have been shown to increase the frequency of nonhomologous integration in yeast. However, the mechanism of such enhanced recombination events is not known. Here, we report that both ionizing radiation and re...     »
Journal title abbreviation:
Nucleic Acids Res
Year:
2007
Journal volume:
35
Journal issue:
15
Pages contribution:
5051-9
Language:
eng
Fulltext / DOI:
doi:10.1093/nar/gkm442
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17652322
Print-ISSN:
0305-1048
TUM Institution:
Frauenklinik und Poliklinik
 BibTeX