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Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article 
Antoniou, AC; Sinilnikova, OM; Simard, J; Léoné, M; Dumont, M; Neuhausen, SL; Struewing, JP; Stoppa-Lyonnet, D; Barjhoux, L; Hughes, DJ; Coupier, I; Belotti, M; Lasset, C; Bonadona, V; Bignon, YJ; Rebbeck, TR; Wagner, T; Lynch, HT; Domchek, SM; Nathanson, KL; Garber, JE; Weitzel, J; Narod, SA; Tomlinson, G; Olopade, OI; Godwin, A; Isaacs, C; Jakubowska, A; Lubinski, J; Gronwald, J; Górski, B; Byrski, T; Huzarski, T; Peock, S; Cook, M; Baynes, C; Murray, A; Rogers, M; Daly, PA; Dorkins, H; Schmut...    »
RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. 
RAD51 is an important component of double-stranded DNA-repair mechanisms that interacts with both BRCA1 and BRCA2. A single-nucleotide polymorphism (SNP) in the 5' untranslated region (UTR) of RAD51, 135G-->C, has been suggested as a possible modifier of breast cancer risk in BRCA1 and BRCA2 mutation carriers. We pooled genotype data for 8,512 female mutation carriers from 19 studies for the RAD51 135G-->C SNP. We found evidence of an increased breast cancer risk in CC homozygotes (hazard ratio...    »
Journal title abbreviation:
Am J Hum Genet 
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TUM Institution:
Frauenklinik und Poliklinik