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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Stemmler, HJ; Schmitt, M; Willems, A; Bernhard, H; Harbeck, N; Heinemann, V
Title:
Ratio of trastuzumab levels in serum and cerebrospinal fluid is altered in HER2-positive breast cancer patients with brain metastases and impairment of blood-brain barrier.
Abstract:
Patients receiving trastuzumab for HER2-overexpressing metastatic breast cancer seem to suffer from an increased risk of brain metastases, even in cases with responsive disease. To evaluate whether trastuzumab is able to penetrate the blood-brain barrier, we measured trastuzumab levels in the serum and in cerebrospinal fluid of metastatic breast cancer patients with brain metastases receiving trastuzumab for HER2-overexpressing metastatic breast cancer. In a pilot study, metastatic breast cancer...    »
Journal title abbreviation:
Anticancer Drugs
Year:
2007
Journal volume:
18
Journal issue:
1
Pages contribution:
23-8
Language:
eng
Fulltext / DOI:
doi:10.1097/01.cad.0000236313.50833.ee
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17159499
Print-ISSN:
0959-4973
TUM Institution:
Frauenklinik und Poliklinik; III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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