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Titel:

Oncostatin M-mediated regulation of KIT-ligand-induced extracellular signal-regulated kinase signaling maintains hematopoietic repopulating activity of Lin-CD34+CD133+ cord blood cells.

Dokumenttyp:
Journal Article; Article
Autor(en):
Oostendorp, RA; Gilfillan, S; Parmar, A; Schiemann, M; Marz, S; Niemeyer, M; Schill, S; Hammerschmid, E; Jacobs, VR; Peschel, C; Götze, KS
Abstract:
We investigated whether KIT signaling was sufficient to maintain human hematopoietic stem cells in culture or whether, as with murine stem cells, signaling through glycoprotein 130 (gp130) is additionally required. Sorted CD34(+)CD133(+)(CD33/CD38/CD71)(-) cells from human umbilical cord blood (UCB) were cultured in the presence of combinations of KIT-ligand (KL) and the gp130 stimulating molecule oncostatin M (OSM). We found that OSM increased KL-induced proliferation, which was accompanied by...     »
Zeitschriftentitel:
Stem Cells
Jahr:
2008
Band / Volume:
26
Heft / Issue:
8
Seitenangaben Beitrag:
2164-72
Sprache:
eng
Volltext / DOI:
doi:10.1634/stemcells.2007-1049
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18499891
Print-ISSN:
1066-5099
TUM Einrichtung:
Frauenklinik und Poliklinik; III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Experimentelle Onkologie und Therapieforschung; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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