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Title:

Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries.

Document type:
Journal Article; Article
Author(s):
Braren, I; Blank, S; Seismann, H; Deckers, S; Ollert, M; Grunwald, T; Spillner, E
Abstract:
BACKGROUND: Allergen-specific IgE and IgG antibodies play pivotal roles in the induction and progression of allergic hypersensitivity reactions. Consequently, monoclonal human IgE and IgG4 antibodies with defined specificity for allergens should be useful in allergy research and diagnostic tests. We used combinatorial antibody libraries and subsequent recombinant production to make and assess IgE, IgG1, and IgG4 allergen-specific antibodies. METHODS: We used phage display to select a synthetic s...     »
Journal title abbreviation:
Clin Chem
Year:
2007
Journal volume:
53
Journal issue:
5
Pages contribution:
837-44
Language:
eng
Fulltext / DOI:
doi:10.1373/clinchem.2006.078360
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17395713
Print-ISSN:
0009-9147
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie
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