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Title:

Ca2+ channel currents and contraction in CaVbeta3-deficient ileum smooth muscle from mouse.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Held, B; Tsvilovskyy, V; Meissner, M; Kaestner, L; Ludwig, A; Mossmang, S; Lipp, P; Freichel, M; Flockerzi, V
Abstract:
Voltage activated L-type Ca(2+) channels are the principal Ca(2+) channels in intestinal smooth muscle cells. They comprise the ion conducting Ca(V)1 pore and the ancillary subunits alpha(2)delta and beta. Of the four Ca(V)beta subunits Ca(V)beta(3) is assumed to be the relevant Ca(V)beta protein in smooth muscle. In protein lysates isolated from mouse ileum longitudinal smooth muscle we could identify the Ca(V)1.2, Ca(V)alpha(2), Ca(V)beta(2) and Ca(V)beta(3) proteins, but not the Ca(V)beta(1)...     »
Journal title abbreviation:
Cell Calcium
Year:
2007
Journal volume:
42
Journal issue:
4-5
Pages contribution:
477-87
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ceca.2007.04.013
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17580090
Print-ISSN:
0143-4160
TUM Institution:
Institut für Pharmakologie und Toxikologie
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