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Title:

Indirect coupling between Cav1.2 channels and ryanodine receptors to generate Ca2+ sparks in murine arterial smooth muscle cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Essin, K; Welling, A; Hofmann, F; Luft, FC; Gollasch, M; Moosmang, S
Abstract:
In arterial vascular smooth muscle cells (VSMCs), Ca(2+) sparks stimulate nearby Ca(2+)-activated K(+) (BK) channels that hyperpolarize the membrane and close L-type Ca(2+) channels. We tested the contribution of L-type Ca(v)1.2 channels to Ca(2+) spark regulation in tibial and cerebral artery VSMCs using VSMC-specific Ca(v)1.2 channel gene disruption in (SMAKO) mice and an approach based on Poisson statistical analysis of activation frequency and first latency of elementary events. Ca(v)1.2 cha...     »
Journal title abbreviation:
J Physiol
Year:
2007
Journal volume:
584
Journal issue:
Pt 1
Pages contribution:
205-19
Language:
eng
Fulltext / DOI:
doi:10.1113/jphysiol.2007.138982
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17673505
Print-ISSN:
0022-3751
TUM Institution:
Institut für Pharmakologie und Toxikologie
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