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Titel:

Dendritic HCN2 channels constrain glutamate-driven excitability in reticular thalamic neurons.

Dokumenttyp:
Journal Article; Comparative Study; Research Support, N.I.H., Extramural
Autor(en):
Ying, SW; Jia, F; Abbas, SY; Hofmann, F; Ludwig, A; Goldstein, PA
Abstract:
Hyperpolarization activated cyclic nucleotide (HCN) gated channels conduct a current, I(h); how I(h) influences excitability and spike firing depends primarily on channel distribution in subcellular compartments. For example, dendritic expression of HCN1 normalizes somatic voltage responses and spike output in hippocampal and cortical neurons. We reported previously that HCN2 is predominantly expressed in dendritic spines in reticular thalamic nucleus (RTN) neurons, but the functional impact of...     »
Zeitschriftentitel:
J Neurosci
Jahr:
2007
Band / Volume:
27
Heft / Issue:
32
Seitenangaben Beitrag:
8719-32
Sprache:
eng
Volltext / DOI:
doi:10.1523/JNEUROSCI.1630-07.2007
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17687049
Print-ISSN:
0270-6474
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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