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Titel:

Necrotic tumor cell death in vivo impairs tumor-specific immune responses.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Gamrekelashvili, J; Krüger, C; Von Wasielewski, R; Hoffmann, M; Huster, KM; Busch, DH; Manns, MP; Korangy, F; Greten, TF
Abstract:
The manner in which cells die is believed to have a major impact on the nature of immune responses to their released Ags. In this study, we present the first direct analysis of tumor-specific immune responses to in vivo occurring tumor cell death through apoptosis or necrosis. Mice bearing thymidine kinase-transfected tumors were treated either with ganciclovir to induce tumor cell apoptosis in vivo or a vascular targeting agent, ZD6126, to induce tumor cell necrosis in vivo. In contrast to tumo...     »
Zeitschriftentitel:
J Immunol
Jahr:
2007
Band / Volume:
178
Heft / Issue:
3
Seitenangaben Beitrag:
1573-80
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17237406
Print-ISSN:
0022-1767
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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