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Title:

NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Schleicher, U; Liese, J; Knippertz, I; Kurzmann, C; Hesse, A; Heit, A; Fischer, JA; Weiss, S; Kalinke, U; Kunz, S; Bogdan, C
Abstract:
Natural killer (NK) cells are sentinel components of the innate response to pathogens, but the cell types, pathogen recognition receptors, and cytokines required for their activation in vivo are poorly defined. Here, we investigated the role of plasmacytoid dendritic cells (pDCs), myeloid DCs (mDCs), Toll-like receptors (TLRs), and of NK cell stimulatory cytokines for the induction of an NK cell response to the protozoan parasite Leishmania infantum. In vitro, pDCs did not endocytose Leishmania...     »
Journal title abbreviation:
J Exp Med
Year:
2007
Journal volume:
204
Journal issue:
4
Pages contribution:
893-906
Language:
eng
Fulltext / DOI:
doi:10.1084/jem.20061293
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17389237
Print-ISSN:
0022-1007
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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