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Titel:

Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Zhu, X; Bagchi, A; Zhao, H; Kirschning, CJ; Hajjar, RJ; Chao, W; Hellman, J; Schmidt, U
Abstract:
OBJECTIVE: Although cardiac dysfunction plays an important role in the pathogenesis of sepsis, the mechanisms that underlie cardiac dysfunction in sepsis remain poorly understood. Bacterial peptidoglycan-associated lipoprotein (PAL), an outer-membrane protein of Gram-negative bacteria, was recently found to be released into the bloodstream in sepsis and to cause inflammation and death in mice. The present studies assessed the effects of PAL on cardiomyocyte function and its signal transduction i...     »
Zeitschriftentitel:
Crit Care Med
Jahr:
2007
Band / Volume:
35
Heft / Issue:
3
Seitenangaben Beitrag:
886-92
Sprache:
eng
Volltext / DOI:
doi:10.1097/01.CCM.0000256723.37586.A2
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17255871
Print-ISSN:
0090-3493
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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