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Titel:

Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kastenmuller, W; Gasteiger, G; Gronau, JH; Baier, R; Ljapoci, R; Busch, DH; Drexler, I
Abstract:
CD8+ T cell responses directed against multiple pathogen-derived epitopes are characterized by defined immunodominance hierarchy patterns. A possible explanation for this phenomenon is that CD8+ T cells of different specificities compete for access to epitopes on antigen-presenting cells, and that the outcome of this so-called cross-competition reflects the number of induced T cells. In our study using a vaccinia virus infection model, we found that T cell cross-competition is highly relevant du...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2007
Band / Volume:
204
Heft / Issue:
9
Seitenangaben Beitrag:
2187-98
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20070489
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17709425
Print-ISSN:
0022-1007
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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