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Titel:

Improved glioblastoma treatment with Ad5/35 fiber chimeric conditionally replicating adenoviruses.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Hoffmann, D; Meyer, B; Wildner, O
Abstract:
Adenovirus type 5 (Ad5)-based vectors have been used in clinical trials for glioblastoma treatment, but the capacity of Ad5 to infect human glioma cells was questioned. Seeking to improve the adenovirus transduction, we tested four Ad5-based vectors differing only in their fiber gene on permanent and short-term cultures of glioblastoma cells. A wild-type fiber Ad5 vector (Ad5.Luc) was compared to an RGD integrin-binding motif-containing fiber adenovirus (AdlucRGD) and the two fiber chimeras Ad5/...     »
Zeitschriftentitel:
J Gene Med
Jahr:
2007
Band / Volume:
9
Heft / Issue:
9
Seitenangaben Beitrag:
764-78
Sprache:
eng
Volltext / DOI:
doi:10.1002/jgm.1076
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17640083
Print-ISSN:
1099-498X
TUM Einrichtung:
Neurochirurgische Klinik und Poliklinik
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