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Document type:
Zeitschriftenaufsatz 
Author(s):
Gnainsky, Yulia; Zfanya, Nofar; Elgart, Michael; Omri, Eman; Brandis, Alexander; Mehlman, Tevie; Itkin, Maxim; Malitsky, Sergey; Adamski, Jerzy; Soen, Yoav 
Title:
Systemic Regulation of Host Energy and Oogenesis by Microbiome-Derived Mitochondrial Coenzymes 
Abstract:
Summary Gut microbiota have been shown to promote oogenesis and fecundity, but the mechanistic basis of remote influence on oogenesis remained unknown. Here, we report a systemic mechanism of influence mediated by bacterial-derived supply of mitochondrial coenzymes. Removal of microbiota decreased mitochondrial activity and ATP levels in the whole-body and ovary, resulting in repressed oogenesis. Similar repression was caused by RNA-based knockdown of mitochondrial function in ovarian follicle c...    »
 
Keywords:
mitochondria, microbiome, oogenesis, metabolomics, riboflavin, 
Journal title:
Cell Reports 
Year:
2021 
Journal volume:
34 
Journal issue:
Pages contribution:
108583 
Print-ISSN:
2211-1247