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Title:

The alternative cap-binding complex is required for antiviral defense in vivo.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Gebhardt, Anna; Bergant, Valter; Schnepf, Daniel; Moser, Markus; Meiler, Arno; Togbe, Dieudonnée; Mackowiak, Claire; Reinert, Line S; Paludan, Søren R; Ryffel, Bernhard; Stukalov, Alexey; Staeheli, Peter; Pichlmair, Andreas
Abstract:
Cellular response to environmental challenges requires immediate and precise regulation of transcriptional programs. During viral infections, this includes the expression of antiviral genes that are essential to combat the pathogen. Transcribed mRNAs are bound and escorted to the cytoplasm by the cap-binding complex (CBC). We recently identified a protein complex consisting of NCBP1 and NCBP3 that, under physiological conditions, has redundant function to the canonical CBC, consisting of NCBP1 a...     »
Journal title abbreviation:
PLoS Pathog
Year:
2019
Journal volume:
15
Journal issue:
12
Fulltext / DOI:
doi:10.1371/journal.ppat.1008155
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31856218
Print-ISSN:
1553-7366
TUM Institution:
Experimentelle Hämatologie (Prof. Schmidt-Supprian); Institut für Virologie
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