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Titel:

Hepatitis-D Virus Infection Is Not Impaired by Innate Immunity but Increases Cytotoxic T-Cell Activity.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Altstetter, Sebastian Maximilian; Quitt, Oliver; Pinci, Francesca; Hornung, Veit; Lucko, Aaron Michael; Wisskirchen, Karin; Jung, Stephanie; Protzer, Ulrike
Abstract:
Approximately 70 million humans worldwide are affected by chronic hepatitis D, which rapidly leads to liver cirrhosis and hepatocellular carcinoma due to chronic inflammation. The triggers and consequences of this chronic inflammation, induced by co-infection with the hepatitis D virus (HDV) and the hepatitis B virus (HBV), are poorly understood. Using CRISPR technology, we characterized the recognition of HDV mono- and co-infection by intracellular innate immunity and determined its influence o...     »
Zeitschriftentitel:
Cells
Jahr:
2021
Band / Volume:
10
Heft / Issue:
11
Volltext / DOI:
doi:10.3390/cells10113253
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34831475
TUM Einrichtung:
Institut für Virologie
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