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Titel:

Immunogenicity and Antiviral Response of Therapeutic Hepatitis B Vaccination in a Mouse Model of HBeAg-Negative, Persistent HBV Infection.

Dokumenttyp:
Journal Article
Autor(en):
Kosinska, Anna D; Festag, Julia; Mück-Häusl, Martin; Festag, Marvin M; Asen, Theresa; Protzer, Ulrike
Abstract:
During the natural course of chronic hepatitis B virus (HBV) infection, the hepatitis B e antigen (HBeAg) is typically lost, while the direct transmission of HBeAg-negative HBV may result in fulminant hepatitis B. While the induction of HBV-specific immune responses by therapeutic vaccination is a promising, novel treatment option for chronic hepatitis B, it remains unclear whether a loss of HBeAg may influence its efficacy or tolerability. We therefore generated an adeno-associated virus (AAV)-...     »
Zeitschriftentitel:
Vaccines (Basel)
Jahr:
2021
Band / Volume:
9
Heft / Issue:
8
Volltext / DOI:
doi:10.3390/vaccines9080841
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34451966
TUM Einrichtung:
Institut für Virologie
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