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Title:

Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Holze, Cathleen; Michaudel, Chloé; Mackowiak, Claire; Haas, Darya A; Benda, Christian; Hubel, Philipp; Pennemann, Friederike L; Schnepf, Daniel; Wettmarshausen, Jennifer; Braun, Marianne; Leung, Daisy W; Amarasinghe, Gaya K; Perocchi, Fabiana; Staeheli, Peter; Ryffel, Bernhard; Pichlmair, Andreas
Abstract:
Reactive oxygen species (ROS) are generated by virus-infected cells; however, the physiological importance of ROS generated under these conditions is unclear. Here we found that the inflammation and cell death induced by exposure of mice or cells to sources of ROS were not altered in the absence of canonical ROS-sensing pathways or known cell-death pathways. ROS-induced cell-death signaling involved interactions among the cellular ROS sensor and antioxidant factor KEAP1, the phosphatase PGAM5 a...     »
Journal title abbreviation:
Nat Immunol
Year:
2018
Journal volume:
19
Journal issue:
2
Pages contribution:
130-140
Fulltext / DOI:
doi:10.1038/s41590-017-0013-y
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29255269
Print-ISSN:
1529-2908
TUM Institution:
Institut für Virologie
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