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Title:

Concentration of Na+-taurocholate-cotransporting polypeptide expressed after in vitro-transcribed mRNA transfection determines susceptibility of hepatoma cells for hepatitis B virus.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Oswald, Andreas; Chakraborty, Anindita; Ni, Yi; Wettengel, Jochen M; Urban, Stephan; Protzer, Ulrike
Abstract:
Infection of hepatocytes by hepatitis B virus (HBV) depends on surface expression of its receptor Na+-taurocholate-cotransporting polypeptide (NTCP), but sufficient NTCP expression is lacking in most cell lines. NTCP can be introduced by plasmid transfection or transduction by viral vectors to render cells permissive for HBV. However, transient transfection of hepatocyte-derived cell lines is inefficient, resulting in inhomogeneous protein expression and does not allow to adapt the level of NTCP...     »
Journal title abbreviation:
Sci Rep
Year:
2021
Journal volume:
11
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41598-021-99263-3
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34611272
Print-ISSN:
2045-2322
TUM Institution:
Institut für Virologie
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