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Titel:

Linear B-Cell Epitopes in Human Norovirus GII.4 Capsid Protein Elicit Blockade Antibodies.

Dokumenttyp:
Journal Article
Autor(en):
Moeini, Hassan; Afridi, Suliman Qadir; Donakonda, Sainitin; Knolle, Percy A; Protzer, Ulrike; Hoffmann, Dieter
Abstract:
Human norovirus (HuNoV) is the leading cause of nonbacterial gastroenteritis worldwide with the GII.4 genotype accounting for over 80% of infections. The major capsid protein of GII.4 variants is evolving rapidly, resulting in new epidemic variants with altered antigenic potentials that must be considered for the development of an effective vaccine. In this study, we identify and characterize linear blockade B-cell epitopes in HuNoV GII.4. Five unique linear B-cell epitopes, namely P2A, P2B, P2C...     »
Zeitschriftentitel:
Vaccines (Basel)
Jahr:
2021
Band / Volume:
9
Heft / Issue:
1
Volltext / DOI:
doi:10.3390/vaccines9010052
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/33466932
TUM Einrichtung:
Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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