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Title:

Prolonged norovirus infections correlate to quasispecies evolution resulting in structural changes of surface-exposed epitopes.

Document type:
Journal Article
Author(s):
Afridi, Suliman Qadir; Usman, Zainab; Donakonda, Sainitin; Wettengel, Jochen Martin; Velkov, Stoyan; Beck, Robert; Gerhard, Markus; Knolle, Percy; Frishman, Dmitrij; Protzer, Ulrike; Moeini, Hassan; Hoffmann, Dieter
Abstract:
In this study, we analyzed norovirus (NoV) evolution in sequential samples of six chronically infected patients. The capsid gene was amplified from stool samples, and deep sequencing was performed. The role of amino acid flexibility in structural changes and ligand binding was studied with molecular dynamics (MD) simulations. Concentrations of capsid-specific antibodies increased in sequential sera. Capsid sequences accumulated mutations during chronic infection, particularly in the surface-expo...     »
Journal title abbreviation:
iScience
Year:
2021
Journal volume:
24
Journal issue:
7
Fulltext / DOI:
doi:10.1016/j.isci.2021.102802
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34355146
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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