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Titel:

Single-Dose Hepatitis A Immunization: 7.5-Year Observational Pilot Study in Nicaraguan Children to Assess Protective Effectiveness and Humoral Immune Memory Response.

Dokumenttyp:
Journal Article; Article
Autor(en):
Mayorga, Orlando; Bühler, Silja; Jaeger, Veronika K; Bally, Seraina; Hatz, Christoph; Frösner, Gert; Protzer, Ulrike; van Damme, Pierre; Egger, Matthias; Herzog, Christian
Abstract:
Universal 2-dose hepatitis A virus (HAV) vaccination of toddlers effectively controls hepatitis A. High vaccine costs, however, impede implementation in endemic countries. To test single-dose vaccination as a possible alternative, we initiated an observational, longitudinal study in Nicaragua, to assess protective effectiveness and-through challenge vaccination-humoral immune memory response. After a 2003 serosurvey, 130 originally seronegative children received one dose of virosomal HAV vaccin...     »
Zeitschriftentitel:
J Infect Dis
Jahr:
2016
Band / Volume:
214
Heft / Issue:
10
Seitenangaben Beitrag:
1498-1506
Sprache:
eng
Volltext / DOI:
doi:10.1093/infdis/jiw411
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27601623
Print-ISSN:
0022-1899
TUM Einrichtung:
Institut für Virologie
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