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Titel:

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ambike, Shubhankar; Cheng, Cho-Chin; Feuerherd, Martin; Velkov, Stoyan; Baldassi, Domizia; Afridi, Suliman Qadir; Porras-Gonzalez, Diana; Wei, Xin; Hagen, Philipp; Kneidinger, Nikolaus; Stoleriu, Mircea Gabriel; Grass, Vincent; Burgstaller, Gerald; Pichlmair, Andreas; Merkel, Olivia M; Ko, Chunkyu; Michler, Thomas
Abstract:
A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) could be small interfering (si)RNAs. So far it is unclear, which viral replication steps can be efficiently inhibited with siRNAs. Here, we report that siRNAs can target genomic RNA (gRNA) of SARS-CoV-2 after cell entry, and thereby terminate replication before start of transcription and prevent virus-induced cell death. Coronaviruses replicate via negative sense RNA intermediates using a unique disco...     »
Zeitschriftentitel:
Nucleic Acids Res
Jahr:
2022
Band / Volume:
50
Heft / Issue:
1
Seitenangaben Beitrag:
333-349
Volltext / DOI:
doi:10.1093/nar/gkab1248
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34928377
Print-ISSN:
0305-1048
TUM Einrichtung:
604; 663; Institut für Virologie (Prof. Protzer)
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