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Titel:

Prolonged norovirus infections correlate to quasispecies evolution resulting in structural changes of surface-exposed epitopes.

Dokumenttyp:
Journal Article
Autor(en):
Afridi, Suliman Qadir; Usman, Zainab; Donakonda, Sainitin; Wettengel, Jochen Martin; Velkov, Stoyan; Beck, Robert; Gerhard, Markus; Knolle, Percy; Frishman, Dmitrij; Protzer, Ulrike; Moeini, Hassan; Hoffmann, Dieter
Abstract:
In this study, we analyzed norovirus (NoV) evolution in sequential samples of six chronically infected patients. The capsid gene was amplified from stool samples, and deep sequencing was performed. The role of amino acid flexibility in structural changes and ligand binding was studied with molecular dynamics (MD) simulations. Concentrations of capsid-specific antibodies increased in sequential sera. Capsid sequences accumulated mutations during chronic infection, particularly in the surface-expo...     »
Zeitschriftentitel:
iScience
Jahr:
2021
Band / Volume:
24
Heft / Issue:
7
Volltext / DOI:
doi:10.1016/j.isci.2021.102802
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34355146
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie ; Roman Herzog Comprehensive Cancer Center
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