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Titel:

Overcoming immune tolerance in chronic hepatitis B by therapeutic vaccination.

Dokumenttyp:
Journal Article; Review
Autor(en):
Dembek, Claudia; Protzer, Ulrike; Roggendorf, Michael
Abstract:
The currently used nucleoside analogs (i.e. entecavir and tenofovir) with high barrier-to-resistance efficiently suppress viral replication, limit inflammation and reduce the sequelae of chronic hepatitis B, but cannot cure the disease and thus have to be applied long-term. Therapeutic vaccination as an approach to cure chronic hepatitis B has shown promising pre-clinical results, nevertheless the proof of its efficacy in clinical trials is still missing. This may be partially due to suboptimal...     »
Zeitschriftentitel:
Curr Opin Virol
Jahr:
2018
Band / Volume:
30
Seitenangaben Beitrag:
58-67
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.coviro.2018.04.003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29751272
Print-ISSN:
1879-6257
TUM Einrichtung:
Institut für Virologie
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