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Title:

Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Walker, Andreas; Schwarz, Tatjana; Brinkmann-Paulukat, Janine; Wisskirchen, Karin; Menne, Christopher; Alizei, Elahe Salimi; Kefalakes, Helenie; Theissen, Martin; Hoffmann, Daniel; Schulze Zur Wiesch, Julian; Maini, Mala K; Cornberg, Markus; Kraft, Anke Rm; Keitel, Verena; Bock, Hans H; Horn, Peter A; Thimme, Robert; Wedemeyer, Heiner; Heinemann, Falko M; Luedde, Tom; Neumann-Haefelin, Christoph; Protzer, Ulrike; Timm, Jörg
Abstract:
BACKGROUND AND AIMS: There is growing interest in T cell-based immune therapies for a functional cure of chronic HBV infection including check-point inhibition, T cell-targeted vaccines or TCR-grafted effector cells. All these approaches depend on recognition of HLA class I-presented viral peptides. The HBV core region 18-27 is an immunodominant target of CD8+ T cells and represents the prime target for T cell-based therapies. Here, a high-resolution analysis of the core18-27 specific CD8+ T cel...     »
Journal title abbreviation:
Front Immunol
Year:
2022
Journal volume:
13
Fulltext / DOI:
doi:10.3389/fimmu.2022.1045498
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36439181
Print-ISSN:
1664-3224
TUM Institution:
Institut für Virologie (Prof. Protzer)
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