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Titel:

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.

Dokumenttyp:
Journal Article
Autor(en):
Fessler, Evelyn; Eckl, Eva-Maria; Schmitt, Sabine; Mancilla, Igor Alves; Meyer-Bender, Matthias F; Hanf, Monika; Philippou-Massier, Julia; Krebs, Stefan; Zischka, Hans; Jae, Lucas T
Abstract:
Mitochondrial fidelity is tightly linked to overall cellular homeostasis and is compromised in ageing and various pathologies1-3. Mitochondrial malfunction needs to be relayed to the cytosol, where an integrated stress response is triggered by the phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) in mammalian cells4,5. eIF2α phosphorylation is mediated by the four eIF2α kinases GCN2, HRI, PERK and PKR, which are activated by diverse types of cellular stress6. However, the ma...     »
Zeitschriftentitel:
Nature
Jahr:
2020
Band / Volume:
579
Heft / Issue:
7799
Seitenangaben Beitrag:
433-437
Volltext / DOI:
doi:10.1038/s41586-020-2076-4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32132706
Print-ISSN:
0028-0836
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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