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Title:

Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis.

Document type:
Journal Article
Author(s):
Zhu, P; Martin, E; Mengwasser, J; Schlag, P; Janssen, KP; Göttlicher, M
Abstract:
Inappropriate transcriptional repression involving histone deacetylases (HDACs) is a prominent cause for the development of leukemia. We now identify faulty expression of a specific mediator of transcriptional repression in a solid tumor. Loss of the adenomatosis polyposis coli (APC) tumor suppressor induces HDAC2 expression depending on the Wnt pathway and c-Myc. Increased HDAC2 expression is found in the majority of human colon cancer explants, as well as in intestinal mucosa and polyps of APC...     »
Journal title abbreviation:
Cancer Cell
Year:
2004
Journal volume:
5
Journal issue:
5
Pages contribution:
455-63
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15144953
Print-ISSN:
1535-6108
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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