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Title:

Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage.

Document type:
Journal Article
Author(s):
Borchard, Sabine; Raschke, Stefanie; Zak, Krzysztof M; Eberhagen, Carola; Einer, Claudia; Weber, Elisabeth; Müller, Sandra M; Michalke, Bernhard; Lichtmannegger, Josef; Wieser, Albrecht; Rieder, Tamara; Popowicz, Grzegorz M; Adamski, Jerzy; Klingenspor, Martin; Coles, Andrew H; Viana, Ruth; Vendelbo, Mikkel H; Sandahl, Thomas D; Schwerdtle, Tanja; Plitz, Thomas; Zischka, Hans
Abstract:
In Wilson disease, excessive copper accumulates in patients' livers and may, upon serum leakage, severely affect the brain according to current viewpoints. Present remedies aim at avoiding copper toxicity by chelation, for example, by D-penicillamine (DPA) or bis-choline tetrathiomolybdate (ALXN1840), the latter with a very high copper affinity. Hence, ALXN1840 may potentially avoid neurological deterioration that frequently occurs upon DPA treatment. As the etiology of such worsening is unclear...     »
Journal title abbreviation:
Life Sci Alliance
Year:
2022
Journal volume:
5
Journal issue:
3
Fulltext / DOI:
doi:10.26508/lsa.202101164
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34857647
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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