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Title:

Flavonoids alter P-gp expression in intestinal epithelial cells in vitro and in vivo.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lohner, K; Schnabele, K; Daniel, H; Oesterle, D; Rechkemmer, G; Göttlicher, M; Wenzel, U
Abstract:
Flavonoids are secondary plant metabolites included in our diet but are also provided in a growing number of supplements. They are suggested to interact with intestinal transport systems including phospho-glycoprotein (P-gp) which mediates the efflux of a variety of xenobiotics back into the gut lumen. In human intestinal Caco-2 cells, we tested the effects of 14 different flavonoids on P-gp expression in vitro. Protein expression levels were quantified by Western blotting, flow cytometry, and r...     »
Journal title abbreviation:
Mol Nutr Food Res
Year:
2007
Journal volume:
51
Journal issue:
3
Pages contribution:
293-300
Language:
eng
Fulltext / DOI:
doi:10.1002/mnfr.200600225
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/17295420
Print-ISSN:
1613-4125
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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