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Title:

UVA inactivates protein tyrosine phosphatases by calpain-mediated degradation.

Document type:
Journal Article
Author(s):
Gulati, P; Markova, B; Göttlicher, M; Böhmer, FD; Herrlich, PA
Abstract:
UV irradiation causes inflammatory and proliferative cellular responses. We have proposed previously that these effects are, to a large extent, caused by the ligand-independent activation of several receptor tyrosine kinases due to the inactivation of their negative control elements, the protein tyrosine phosphatases (PTPs). We examined the mechanism of this inactivation and found that, in addition to reversible oxidation of PTPs, UV triggers a novel mechanism: induced degradation of PTPs by cal...     »
Journal title abbreviation:
EMBO Rep
Year:
2004
Journal volume:
5
Journal issue:
8
Pages contribution:
812-7
Language:
eng
Fulltext / DOI:
doi:10.1038/sj.embor.7400190
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15247926
Print-ISSN:
1469-221X
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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