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Title:

1,2:3,4-Diepoxybutane in blood of male B6C3F1 mice and male Sprague-Dawley rats exposed to 1,3-butadiene.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Csanády, GA; Steinhoff, R; Riester, MB; Semder, B; Putz, C; Li, Q; Richter, N; Kessler, W; Klein, D; Filser, JG
Abstract:
The important industrial chemical 1,3-butadiene (BD; CAS Registry Number: 106-99-0) is a potent carcinogen in B6C3F1 mice and a weak one in Sprague-Dawley rats. This difference is mainly attributed to the species-specific burden by the metabolically formed 1,2:3,4-diepoxybutane (DEB). However, only limited data exist on the DEB blood burden of rodents at BD concentrations below 100 ppm. Considering this, DEB concentrations were determined in the blood of mice and rats immediately after 6h expos...     »
Journal title abbreviation:
Toxicol Lett
Year:
2011
Journal volume:
207
Journal issue:
3
Pages contribution:
286-90
Language:
eng
Fulltext / DOI:
doi:10.1016/j.toxlet.2011.09.027
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21983653
Print-ISSN:
0378-4274
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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