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Titel:

Mitochondrial copper homeostasis and its derailment in Wilson disease.

Dokumenttyp:
Journal Article
Autor(en):
Zischka, Hans; Einer, Claudia
Abstract:
In mitochondria, copper is a Janus-faced trace element. While it is the essential cofactor of the mitochondrial cytochrome c oxidase, a surplus of copper can be highly detrimental to these organelles. On the one hand, mitochondria are strictly dependent on adequate copper supply for proper respiratory function, and the molecular mechanisms for metalation of the cytochrome c oxidase have been largely characterized. On the other hand, copper overload impairs mitochondria and uncertainties exist co...     »
Zeitschriftentitel:
Int J Biochem Cell Biol
Jahr:
2018
Band / Volume:
102
Seitenangaben Beitrag:
71-75
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.biocel.2018.07.001
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29997057
Print-ISSN:
1357-2725
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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