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Titel:

The exceptional sensitivity of brain mitochondria to copper.

Dokumenttyp:
Journal Article
Autor(en):
Borchard, Sabine; Bork, Francesca; Rieder, Tamara; Eberhagen, Carola; Popper, Bastian; Lichtmannegger, Josef; Schmitt, Sabine; Adamski, Jerzy; Klingenspor, Martin; Weiss, Karl-Heinz; Zischka, Hans
Abstract:
Wilson disease (WD) is characterized by a disrupted copper homeostasis resulting in dramatically increased copper levels, mainly in liver and brain. While copper damage to mitochondria is an established feature in WD livers, much less is known about such detrimental copper effects in other organs. We therefore assessed the mitochondrial sensitivity to copper in a tissue specific manner, namely of isolated rat liver, kidney, heart, and brain mitochondria. Brain mitochondria presented with excepti...     »
Zeitschriftentitel:
Toxicol In Vitro
Jahr:
2018
Band / Volume:
51
Seitenangaben Beitrag:
11-22
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.tiv.2018.04.012
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29715505
Print-ISSN:
0887-2333
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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