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Titel:

Kinetics of ethylene and ethylene oxide in subcellular fractions of lungs and livers of male B6C3F1 mice and male fischer 344 rats and of human livers.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Li, Q; Csanády, GA; Kessler, W; Klein, D; Pankratz, H; Putz, C; Richter, N; Filser, JG
Abstract:
Ethylene (ET) is metabolized in mammals to the carcinogenic ethylene oxide (EO). Although both gases are of high industrial relevance, only limited data exist on the toxicokinetics of ET in mice and of EO in humans. Metabolism of ET is related to cytochrome P450-dependent mono-oxygenase (CYP) and of EO to epoxide hydrolase (EH) and glutathione S-transferase (GST). Kinetics of ET metabolism to EO and of elimination of EO were investigated in headspace vessels containing incubations of subcellular...     »
Zeitschriftentitel:
Toxicol Sci
Jahr:
2011
Band / Volume:
123
Heft / Issue:
2
Seitenangaben Beitrag:
384-98
Sprache:
eng
Volltext / DOI:
doi:10.1093/toxsci/kfr194
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21785163
Print-ISSN:
1096-6080
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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