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Title:

Single cell polarity in liquid phase facilitates tumour metastasis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Lorentzen, Anna; Becker, Paul F; Kosla, Jan; Saini, Massimo; Weidele, Kathrin; Ronchi, Paolo; Klein, Corinna; Wolf, Monika J; Geist, Felix; Seubert, Bastian; Ringelhan, Marc; Mihic-Probst, Daniela; Esser, Knud; Roblek, Marko; Kuehne, Felix; Bianco, Gaia; O'Connor, Tracy; Müller, Quentin; Schuck, Kathleen; Lange, Sebastian; Hartmann, Daniel; Spaich, Saskia; Groß, Olaf; Utikal, Jochen; Haferkamp, Sebastian; Sprick, Martin R; Damle-Vartak, Amruta; Hapfelmeier, Alexander; Hüser, Norbert; Protzer, Ul...     »
Abstract:
Dynamic polarisation of tumour cells is essential for metastasis. While the role of polarisation during dedifferentiation and migration is well established, polarisation of metastasising tumour cells during phases of detachment has not been investigated. Here we identify and characterise a type of polarisation maintained by single cells in liquid phase termed single-cell (sc) polarity and investigate its role during metastasis. We demonstrate that sc polarity is an inherent feature of cells from...     »
Journal title abbreviation:
Nat Commun
Year:
2018
Journal volume:
9
Journal issue:
1
Pages contribution:
887
Language:
eng
Fulltext / DOI:
doi:10.1038/s41467-018-03139-6
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29491397
Print-ISSN:
2041-1723
TUM Institution:
Chirurgische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Statistik und Epidemiologie; Institut für Virologie
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