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Title:

Titin Circular RNAs Create a Back-Splice Motif Essential for SRSF10 Splicing.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Tijsen, Anke J; Cócera Ortega, Lucía; Reckman, Yolan J; Zhang, Xiaolei; van der Made, Ingeborg; Aufiero, Simona; Li, Jiuru; Kamps, Selina C; van den Bout, Anouk; Devalla, Harsha D; van Spaendonck-Zwarts, Karin Y; Engelhardt, Stefan; Gepstein, Lior; Ware, James S; Pinto, Yigal M
Abstract:
BACKGROUND: TTN (Titin), the largest protein in humans, forms the molecular spring that spans half of the sarcomere to provide passive elasticity to the cardiomyocyte. Mutations that disrupt the TTN transcript are the most frequent cause of hereditary heart failure. We showed before that TTN produces a class of circular RNAs (circRNAs) that depend on RBM20 to be formed. In this study, we show that the back-splice junction formed by this class of circRNAs creates a unique motif that binds SRSF10...     »
Journal title abbreviation:
Circulation
Year:
2021
Journal volume:
143
Journal issue:
15
Pages contribution:
1502-1512
Fulltext / DOI:
doi:10.1161/CIRCULATIONAHA.120.050455
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33583186
Print-ISSN:
0009-7322
TUM Institution:
Institut für Pharmakologie und Toxikologie
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