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Title:

Nuclear calcineurin is a sensor for detecting Ca2+ release from the nuclear envelope via IP3R.

Document type:
Article; Journal Article
Author(s):
Olivares-Florez, Silvana; Czolbe, Martin; Riediger, Fabian; Seidlmayer, Lea; Williams, Tatjana; Nordbeck, Peter; Strasen, Jörn; Glocker, Cristina; Jänsch, Monique; Eder-Negrin, Petra; Arias-Loza, Paula; Mühlfelder, Melanie; Plačkić, Jelena; Heinze, Katrin G; Molkentin, Jeffery D; Engelhardt, Stefan; Kockskämper, Jens; Ritter, Oliver
Abstract:
In continuously beating cells like cardiac myocytes, there are rapid alterations of cytosolic Ca2+ levels. We therefore hypothesize that decoding Ca2+ signals for hypertrophic signaling requires intracellular Ca2+ microdomains that are partly independent from cytosolic Ca2+. Furthermore, there is a need for a Ca2+ sensor within these microdomains that translates Ca2+ signals into hypertrophic signaling. Recent evidence suggested that the nucleus of cardiac myocytes might be a Ca2+ microdomain an...     »
Journal title abbreviation:
J Mol Med
Year:
2018
Journal volume:
96
Journal issue:
11
Pages contribution:
1239-1249
Fulltext / DOI:
doi:10.1007/s00109-018-1701-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30293136
Print-ISSN:
0946-2716
TUM Institution:
Institut für Pharmakologie und Toxikologie
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