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Title:

Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators.

Document type:
Journal Article
Author(s):
Matei, Alexandru-Emil; Beyer, Christian; Györfi, Andrea-Hermina; Soare, Alina; Chen, Chih-Wei; Dees, Clara; Bergmann, Christina; Ramming, Andreas; Friebe, Andreas; Hofmann, Franz; Distler, Oliver; Schett, Georg; Distler, Jörg H W
Abstract:
OBJECTIVES: Stimulators of soluble guanylate cyclase (sGC) are currently investigated in clinical trials for the treatment of fibrosis in systemic sclerosis (SSc). In this study, we aim to investigate the role of protein kinases G (PKG) as downstream mediators of sGC-cyclic guanosine monophosphate (cGMP) in SSc. METHODS: Mice with combined knockout of PKG1 and 2 were challenged with bleomycin and treated with the sGC stimulator BAY 41-2272. Fibroblasts were treated with BAY 41-2272 and with the...     »
Journal title abbreviation:
Ann Rheum Dis
Year:
2018
Journal volume:
77
Journal issue:
3
Fulltext / DOI:
doi:10.1136/annrheumdis-2017-212489
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29311148
Print-ISSN:
0003-4967
TUM Institution:
Institut für Pharmakologie und Toxikologie
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