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Title:

A universal model of RNA.DNA:DNA triplex formation accurately predicts genome-wide RNA-DNA interactions.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Warwick, Timothy; Seredinski, Sandra; Krause, Nina M; Bains, Jasleen Kaur; Althaus, Lara; Oo, James A; Bonetti, Alessandro; Dueck, Anne; Engelhardt, Stefan; Schwalbe, Harald; Leisegang, Matthias S; Schulz, Marcel H; Brandes, Ralf P
Abstract:
RNA.DNA:DNA triple helix (triplex) formation is a form of RNA-DNA interaction which regulates gene expression but is difficult to study experimentally in vivo. This makes accurate computational prediction of such interactions highly important in the field of RNA research. Current predictive methods use canonical Hoogsteen base pairing rules, which whilst biophysically valid, may not reflect the plastic nature of cell biology. Here, we present the first optimization approach to learn a probabilis...     »
Journal title abbreviation:
Brief Bioinform
Year:
2022
Journal volume:
23
Journal issue:
6
Fulltext / DOI:
doi:10.1093/bib/bbac445
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/36239395
Print-ISSN:
1467-5463
TUM Institution:
Institut für Pharmakologie und Toxikologie
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