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Title:

Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Haddad, George; Kölling, Malte; Wegmann, Urs A; Dettling, Angela; Seeger, Harald; Schmitt, Roland; Soerensen-Zender, Inga; Haller, Hermann; Kistler, Andreas D; Dueck, Anne; Engelhardt, Stefan; Thum, Thomas; Mueller, Thomas F; Wüthrich, Rudolf P; Lorenzen, Johan M
Abstract:
BACKGROUND: Renal ischemia-reperfusion (I/R) injury is a major cause of AKI. Noncoding RNAs are intricately involved in the pathophysiology of this form of AKI. Transcription of hypoxia-induced, long noncoding RNA H19, which shows high embryonic expression and is silenced in adults, is upregulated in renal I/R injury. METHODS: Lentivirus-mediated overexpression, as well as antisense oligonucleotide-based silencing, modulated H19 in vitro. In vivo analyses used constitutive H19 knockout mice. In...     »
Journal title abbreviation:
J Am Soc Nephrol
Year:
2021
Journal volume:
32
Journal issue:
2
Pages contribution:
323-341
Fulltext / DOI:
doi:10.1681/ASN.2020060775
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33478972
Print-ISSN:
1046-6673
TUM Institution:
Institut für Pharmakologie und Toxikologie
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