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Title:

AntimiR-132 Attenuates Myocardial Hypertrophy in an Animal Model of Percutaneous Aortic Constriction.

Document type:
Journal Article
Author(s):
Hinkel, Rabea; Batkai, Sandor; Bähr, Andrea; Bozoglu, Tarik; Straub, Sarah; Borchert, Tobias; Viereck, Janika; Howe, Andrea; Hornaschewitz, Nadja; Oberberger, Lisa; Jurisch, Victoria; Kozlik-Feldmann, Rainer; Freudenthal, Franz; Ziegler, Tilman; Weber, Christian; Sperandio, Markus; Engelhardt, Stefan; Laugwitz, Karl Ludwig; Moretti, Alessandra; Klymiuk, Nik; Thum, Thomas; Kupatt, Christian
Abstract:
BACKGROUND: Pathological cardiac hypertrophy is a result of afterload-increasing pathologies including untreated hypertension and aortic stenosis. It features progressive adverse cardiac remodeling, myocardial dysfunction, capillary rarefaction, and interstitial fibrosis often leading to heart failure. OBJECTIVES: This study aimed to establish a novel porcine model of pressure-overload-induced heart failure and to determine the effect of inhibition of microribonucleic acid 132 (miR-132) on heart...     »
Journal title abbreviation:
J Am Coll Cardiol
Year:
2021
Journal volume:
77
Journal issue:
23
Pages contribution:
2923-2935
Fulltext / DOI:
doi:10.1016/j.jacc.2021.04.028
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34112319
Print-ISSN:
0735-1097
TUM Institution:
1693; Arbeitsgruppe Tissue Engineering und Regenerative Medizin; Institut für Pharmakologie und Toxikologie; Klinik und Poliklinik für Innere Medizin I, Kardiologie
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