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Title:

Viral Vector-Based Targeting of miR-21 in Cardiac Nonmyocyte Cells Reduces Pathologic Remodeling of the Heart.

Document type:
Journal Article; Article
Author(s):
Ramanujam, Deepak; Sassi, Yassine; Laggerbauer, Bernhard; Engelhardt, Stefan
Abstract:
Systemic inhibition of miR-21 has proven effective against myocardial fibrosis and dysfunction, while studies in cardiac myocytes suggested a protective role in this cell type. Considering potential implications for therapy, we aimed to determine the cell fraction where miR-21 exerts its pathological activity. We developed a viral vector-based strategy for gene targeting of nonmyocyte cardiac cells in vivo and compared global to cardiac myocyte-specific and nonmyocyte-specific deletion of miR-21...     »
Journal title abbreviation:
Mol Ther
Year:
2016
Journal volume:
24
Journal issue:
11
Pages contribution:
1939-1948
Language:
eng
Fulltext / DOI:
doi:10.1038/mt.2016.166
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27545313
Print-ISSN:
1525-0016
TUM Institution:
Institut für Pharmakologie und Toxikologie
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