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Titel:

Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice.

Dokumenttyp:
Article; Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Ziegler, Karin A; Ahles, Andrea; Wille, Timo; Kerler, Julia; Ramanujam, Deepak; Engelhardt, Stefan
Abstract:
Aims: Cardiac inflammation has been suggested to be regulated by the sympathetic nervous system (SNS). However, due to the lack of methodology to surgically eliminate the myocardial SNS in mice, neuronal control of cardiac inflammation remains ill-defined. Here, we report a procedure for local cardiac sympathetic denervation in mice and tested its effect in a mouse model of heart failure post-myocardial infarction. Methods and results: Upon preparation of the carotid bifurcation, the right and t...     »
Zeitschriftentitel:
Cardiovasc Res
Jahr:
2018
Band / Volume:
114
Heft / Issue:
2
Seitenangaben Beitrag:
291-299
Volltext / DOI:
doi:10.1093/cvr/cvx227
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29186414
Print-ISSN:
0008-6363
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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