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Titel:

Secretin activates brown fat and induces satiation.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Laurila, Sanna; Sun, Lihua; Lahesmaa, Minna; Schnabl, Katharina; Laitinen, Kirsi; Klén, Riku; Li, Yongguo; Balaz, Miroslav; Wolfrum, Christian; Steiger, Katja; Niemi, Tarja; Taittonen, Markku; U-Din, Mueez; Välikangas, Tommi; Elo, Laura L; Eskola, Olli; Kirjavainen, Anna K; Nummenmaa, Lauri; Virtanen, Kirsi A; Klingenspor, Martin; Nuutila, Pirjo
Abstract:
Brown adipose tissue (BAT) thermogenesis is activated by feeding. Recently, we revealed a secretin-mediated gut-BAT-brain axis, which stimulates satiation in mice, but the purpose of meal-induced BAT activation in humans has been unclear. In this placebo-controlled, randomized crossover study, we investigated the effects of intravenous secretin on BAT metabolism (measured with [18F]FDG and [15O]H2O positron emission tomography) and appetite (measured with functional magnetic resonance imaging) i...     »
Zeitschriftentitel:
Nat Metab
Jahr:
2021
Band / Volume:
3
Heft / Issue:
6
Seitenangaben Beitrag:
798-809
Volltext / DOI:
doi:10.1038/s42255-021-00409-4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34158656
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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